ABSTRACT

Advances in nanotechnology have led to the development of a plethora of commercial applications of diverse nanomaterials, thereby substantially increasing chances of exposure to nanomaterials. This has raised global concern regarding their fate in biological systems, resulting in a demand for parallel risk assessment. In view of this, it becomes essential to systematically and thoroughly analyze absorption, distribution, metabolism, and excretion (ADME) of nanomaterials for the development of safe nanomaterials. In this chapter, we present the current understanding regarding the ADME profile of nanomaterials. The chapter will highlight the current status of nanotoxicity evaluation considering the fate and effect of nanodrugs in biological systems using a pharmacokinetic approach.