ABSTRACT
With the establishment of a link between dietary habits and human health, phytochemicals possessing health-promoting functionalities, and hence of nutraceutical importance, are receiving increased attention from scientific and nonscientific communities. However, due to insufficient solubility, low permeability, extensive physicochemical and metabolic transformation, and rapid elimination, these molecules often exhibit limited clinical application. Smart formulation design and development using nanostructured systems are now being explored for improving the compromised bio profile of these phytochemicals. In this chapter we will discuss application of these strategies to enhance bioavailability and activity of two model phytochemicals, curcumin and sesamol, in a variety of pathologies.
