Leprosy continues to haunt human civilization. Numerous programs and control measures have been implemented, but somehow, the disease is everlasting. Lepromatous leprosy, one of the polar presentations of the disease, is thought to contribute to high communicability of the disease. The severity of systemic involvement, disabilities, and deformities adds to the suffering of the patient. In this chapter, we briefly discuss the clinical features and management of lepromatous leprosy.