ABSTRACT
Abstract ................................................................................................. 390 13.1 Introduction ................................................................................ 390 13.2 Advantage .................................................................................. 393 13.3 Disadvantage .............................................................................. 395 13.4 Formulation ................................................................................ 395 13.5 Characterization of Nanoemulsions ........................................... 397 13.6 Properties ................................................................................... 399 13.7 Applications ............................................................................... 401 13.8 Major Challenges of Nanoemulsion Drug Delivery Systems .... 417 13.9 Conclusion and Future Perspectives .......................................... 417 Keywords .............................................................................................. 418 References ............................................................................................. 418
PREETI KHULBE*
School of Pharmaceutical Sciences, Jaipur National University, Jaipur 302017, India
*E-mail: khulbe.preeti@yahoo.in
ABSTRACT
Nanoemulsion can be defined as emulsion having droplet sizes with “nano” range. Both hydrophilic and lipophilic drugs can be used in nanoemulsion. It protects the drug from hydrolysis and oxidation due to encapsulation in oil droplet. It also provides taste masking. Different characterization parameters for nanoemulsion include transmission microscopy, nanoemulsion droplet size analysis, consistency determination, index of refraction, in vitro skin permeation studies, skin irritation check, in vivo efficacy study, thermodynamic stability studies, and surface characteristics. This chapter covers different applications, advantages, disadvantages, and methods of preparation of nanoemulsion. The future scopes of nanoemulsion are also discussed in this chapter.
