ABSTRACT
Fentanyl has a potency ratio 100 times stronger than morphine. Oxycodone is a receptor agonist of mu and kappa opioids, structurally similar to codeine, but pharmacodynamically similar to morphine. The aim of this study was to determine the comparison of time achievement of VAS < 3 on oxycodone. This study used a double-blind, randomised clinical trial, collecting 48 samples from participants aged 21-60 years, PS ASA I-II. Oxycodone (A): fentanyl (B) (initial bolus 5 mg than continuous infusion dose of 1 mg/hour: initial bolus 5 cc of NaCl 0.9% than continuous infusion dose of 0.5 mcg/hour) with significance level 95% (p < 0.05). Average length of surgery fentanyl: oxycodone (218.96 ± 53.38 minutes: 191.87 ± 80.10, p > 0.05). Oxycodone is faster in achieving VAS < 3 compared with fentanyl intravenous infusion.
