chapter  38
4 Pages

The effect of intranasal corticosteroids on nasal polyps as assessed by expression of Tumour Necrosis Factor Alpha (TNF-α)

WithJ.K. Siow, A.Y.M. Rambe, E.M. Surbakti, D. Munir, L.I. Laksmi, P. Eyanoer

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Tumour Necrosis Factor Alpha (TNFa) is one of the pro-inflammatory cytokines that play an important role in the pathogenesis of nasal polyps. Fluticasone furoate is the most potent inhibitor of NF-kB activation and TNF release. The aim of this study was to determine the effect of nasal spray fluticasone furoate on TNFa expression of nasal polyps. This study was analytic with an experimental quasi-study design, performed on 16 cases of nasal polyps obtained with non-probability consecutive sampling. 16 samples, TNFa expression in nasal polyps before treatment with fluticasone furoate was mostly overexpression (87.5%) while post-treatment was found to be negative (81.3%). Data analysis showed a significant decrease in TNFa expression after therapy (p = 0.001). There was no significant correlation between nasal polyp decline and decreased expression of TNFa in nasal polyps after fluticasone furoate therapy (p = 0.136). Fluticasone furoate has been shown to decrease TNFa expression in nasal polyps and significantly reduce polyp stages.