chapter  39
4 Pages

Immuno-expression of the p53 mutant protein in sinonasal squamous cell carcinoma

WithA. Yudhistira, R.A. Asnir, Farhat, D. Indriani, H.M.N.D. Lubis

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Sinonasal squamous cell carcinomas are malignant tumours occurring in the nasal cavity and paranasal sinuses. The p53 protein is a tumour suppressor gene, functioning in processes of cellular apoptosis, differentiation, ageing and angiogenesis. The purpose of this study was to observe the expression of the p53 mutant protein in sinonasal squamous cell carcinoma. This was an observational study in Haji Adam Malik General Hospital where we performed the immunohistochemical examination on paraffin blocks from 30 patients with sinonasal carcinoma who had undergone surgery. Out of 30 samples of sinonasal carcinoma blocks, we found 16 samples with an overexpression of the p53 mutant protein (53.3%).