Correlation of BDNF and cognitive function in smoking Batak male schizophrenic patients
Schizophrenia is a complex neurodevelopmental disorder with impaired cognitive function as a major element. BDNF may be a marker of abnormal neuronal development and neurotransmission in schizophrenia. Cognitive function often correlates significantly with awareness of pain, social skills and the presence of a delayed return to normal life. The purpose of this study was to look at the association of serum levels of BDNF and cognitive function in Batak male, schizophrenic patients who smoke and have a history of using risperidone treatment. This study was a cross-sectional, correlative numerical study in order to assess cognitive function using the Montreal Assessment Cognitive Instrument Indonesia (MoCA-Ina) version. BDNF serum levels were analysed using the quantitative sandwich enzyme, immunoassay. There was a significant correlation between the MoCA-Ina score and BDNF serum levels with a correlation value of 0.441 showing a positive correlation with moderate correlation strength (r = 0.4 <0.6).