chapter  54
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Association of Matrix Metalloproteinase 2 (MMP 2) and Tissue Inhibitor Matrix Metalloproteinase 2 (TIMP 2) and bone destruction in atticoantral type of Chronic Suppurative Otitis Media (CSOM)

WithH.A. Asroel, R.S.P. Wulandari, A. Aboet, F. Zaluchu, S. Eliandy

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To determine an association between Matrix Metalloproteinase 2 (MMP 2) and Tissue Inhibitor Matrix Metalloproteinase 2 (TIMP 2) and bone destruction in atticoan- tral type Chronic Suppurative Otitis Media (CSOM) in patients at Haji Adam Malik General Hospital. This analytical cross-sectional study included cholesteatoma from atticoantral type CSOM taken and made into paraffin blocks. These tissues were immunohistochemically examined by assessing MMP 2 and TIMP 2 immunoreactivity at the anatomical pathology installation. MMP 2 overexpression (36 sample, 90%), however, samples that overexpressed and did not overexpress TIMP 2 were relatively even, 21 (52.5%) and 19 (47.5%), respectively. MMP 2 expression was not significantly associated with TIMP 2 (p = 0.342). MMP 2 and TIMP 2 expressions were not significantly associated, and TIMP 2 with bone destruction were not significantly associated in atticoantral type CSOM.