Expression of p53 as a Potential Marker of Muscle Invasiveness in Bladder Cancer
To analyse the association of p53 and muscle invasiveness in bladder cancer. The samples of this study are patients with bladder cancer. The samples were then classified into Non-Muscle Invasive Bladder Cancer (NMIBC) and Muscle Invasive Bladder Cancer (MIBC). All samples then underwent immunohistochemistry assay for p53, and then group analysed. p53 was expressed in 29 (96.7%) patients with MIBC and 23 (76.7%) patients with NMIBC. There was a significant difference in the expression of p53 between both groups (OR 8.8; 95% CI: 1.012- 76.96). The expression of p53 was significantly associated with muscle invasiveness of bladder cancer. Prospective study is needed to determine its potential in predicting muscle invasiveness of bladder cancer.