chapter  59
4 Pages

Expression of p53 as a Potential Marker of Muscle Invasiveness in Bladder Cancer

WithS.M. Warli, L.I. Laksmi, F. Safriadi, R. Umbas

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To analyse the association of p53 and muscle invasiveness in bladder cancer. The samples of this study are patients with bladder cancer. The samples were then classified into Non-Muscle Invasive Bladder Cancer (NMIBC) and Muscle Invasive Bladder Cancer (MIBC). All samples then underwent immunohistochemistry assay for p53, and then group analysed. p53 was expressed in 29 (96.7%) patients with MIBC and 23 (76.7%) patients with NMIBC. There was a significant difference in the expression of p53 between both groups (OR 8.8; 95% CI: 1.012- 76.96). The expression of p53 was significantly associated with muscle invasiveness of bladder cancer. Prospective study is needed to determine its potential in predicting muscle invasiveness of bladder cancer.