Increased expression of TGF-β in the cochlear fibroblast of diabetic model rats
The cochlea, as a microvascular organ, is very susceptible to conditions that result in a disruption of vascularisation. Transforming Growth Factor-β (TGF-β) plays a role in diabetic complication process, especially in microangiopathy, due to its role in thickening the basal membrane of the vessel. This study aims to see the TGF-β expression in cochlear fibroblasts diabetic model rats. Eight male Rattus norvegicus were divided into two groups> Group 1: control, rats were injected only with a single dose of sodium citrate intraperitoneally and then terminated on day 5. Group 2: rats were injected with intraperitoneal single-dose Streptozotocin (STZ) and terminated on day 5. Samples were terminated and necropsied for the removal of their cochlear tissue and their TGF-β expression determined by immunohistochemical examination. There was a significant difference (p <0.05) in TGF-β expression in group 1 compared to group 2.