chapter  70
4 Pages

Association of ascariasis with IL-10 enzyme gene polymorphism in diabetes mellitus patients with tuberculosis

WithN.K. Arrasyid, Y.S. Pane, M.R.Z. Tala, M.I. Sari, D.K. Sari

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Hyperglycaemia causes a phagocytic injection of Polymorphonuclear Leukocyte (PMN), which is associated with an increased frequency of infection. Impaired function of PMN phagocytosis is associated with 330an increased risk of infection that stimulates the formation of proinflammatory cytokines. In chronic worm infections, Treg cell activation results in IL-10 production, which plays a role in class switching antibody response in which IgE-producing cells switch to produce IgG4 which inhibits effector effranulation. This study aims to examine the correlation between Soil-Transmitted Helminth (STH) infection and IL-10 enzyme gene polymorphism among patients with both Diabetes Mellitus (DM) and Tuberculosis (Tb). The results showed that negative significant correlation between STH infection and IL-10 enzyme gene polymorphism among DM and Tb patients.