ABSTRACT
This chapter aims to provide an overview of some strategies in nanomedicine employed to overcome the toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs). It discusses breakthroughs in the development of nanodelivery systems for NSAIDs and considers diverse approaches to improve the safety of NSAID therapy, namely increasing the drug's bioavailability, targeting inflamed sites, avoiding gastric release and enhancing skin permeationa. The development of nanodelivery systems seems to be a valuable approach to accomplish an efficacious and safe NSAID therapy. Nanoparticles (NPs) are versatile platforms to achieve better drug pharmacokinetic and pharmacodynamic profiles, thereby avoiding the drug's toxicity and/or improving the drug's therapeutic efficacy. In fact, a wide range of NPs have been designed to increase the bioavailability of NSAIDs, to target the inflamed areas, to avoid their gastric release, and to enhance the skin permeation of NSAIDs.
