ABSTRACT
Imaging, specifically magnetic resonance imaging (MRI), is a powerful clinical and research modality that can display a wide range of static, dynamic, and biologically relevant features of brain lesions and offers a valuable macroscopic complement to corresponding molecular or genomic data. As a result, MRI has become an integral component in various aspects of clinical care ranging from diagnosis, pre-surgical planning, and post-treatment follow-up in brain tumors. Recently, studies demonstrating the correlation between imaging features and molecular events, termed radiogenomics (also known as imaging genomics), have augmented the role of MRI in tumor characterization. These studies have the potential to not only better understand the complex molecular biological transformations behind glioblastoma development, but can also uncover macroscopic imaging biomarkers correlated to molecular events, opening the door to more efficient personalized treatment. Radiomics, an automated imaging feature extraction method that can extract numerous imaging characteristics from standard medical images, has also widened the role of imaging by providing microscale imaging information. This paper discusses the current state of brain tumor imaging in clinical care with the emerging field of radiogenomics and radiomics.
