ABSTRACT
Translational medicine aims at transferring results from novel research immediately out of the laboratory to improve patient treatment and health care, that is from bench to bedside (B2B). This chapter reviews existing information technology (IT) systems supporting research and clinical trials and healthcare information systems (HIS) architectures for research and patient care. A Clinical Trial Management System (CTMS) is used to manage the high number of trials, subjects, and persons involved. HISs provide a common source of information about a patient's health history. In the hospital, these systems enhance the ability of healthcare professionals to coordinate care by providing a patient's health information and visit history at the place and time that it is needed. The system architecture is adopted from the well-established structure of information systems that are already in use for medical care. The chapter finally presents a system architecture and implementation to automate the CAD in clinical trials, in particular for signal- and image-based biomarkers.
