chapter  10
13 Pages

Bacteriophage Involvement in Neurodegenerative Diseases

WithGeorge Tetz, Victor Tetz

There are a variety of neurodegenerative diseases characterized by a progressive cognitive decline accompanied by memory loss, and Alzheimer’s disease is the most common among them. 1 These cognitive symptoms and neurodegeneration are primarily related to neuronal death caused by deposits of misfolded proteins in the brain—β-amyloid and tau proteins in Alzheimer’s, α-synuclein in Parkinson’s disease, and SOD1 and TDP-43 in amyotrophic lateral sclerosis (ALS).2,3 The appearance of these extracellular protein aggregates results in neuronal death and synapse loss. This degradation in turn contributes to neural atrophy that, at least in the initial stages of Alzheimer’s disease, is localized within the hippocampus and the entorhinal cortex.4,5