ABSTRACT
Embryo morphology annotation-based selection, which posits that morphologic assessment of preimplantation embryos is a central tool in the selection of viable embryos, has dominated research for the past 20 years. More recently, time-lapse (TL) dynamic embryo monitoring annotations and algorithms were purported as better predictors of blastocyst development, aneuploidy, and implantation. This chapter reviews the evidence underpinning the use of time-lapse imaging (TLI) for embryological and clinical outcomes prediction, appraises available clinical trials, and considers confounding variables that limit the reliability of the evidence.
