This chapter introduces the most common approaches in recent years to the realization of an artificial electronic skin system by employing organic electronics. The human tactile system, unlike others sensory systems, is not located in a specific apparatus but is distributed throughout different parts of the human body, such as skin, muscles and skeleton. The skin is the largest organ in the human body and is a very important part of the tactile system; it performs the functions of protecting the body from bacteria, viruses, and potentially damage by external substances. A capacitive sensor takes advantage of the structure and working principles of capacitors. The working principle of resistive sensors is based on the modulation of the resistance of a particular material due to pressure stimulation or due to temperature stimulation. Lai et al. reported a different approach for the fabrication of organic charge-modulated FETs as tactile sensors.