ABSTRACT
The objective is to determine the effect of Jamu X as complement therapy to decrease Fasting Plasma Glucose (FPG), 2-hours Postprandial Plasma Glucose (2-h PPG), and HbA1C in patients with type-2 diabetes mellitus receiving metformin therapy at UGM hospital. This research was conducted in a single center randomized double-blind clinical trial. Forty seven type-2 diabetes mellitus patients with metformin in UGM hospital who met the inclusion criteria were randomly divided into herbal group and placebo. The change in FPG, 2-h PPG and HbA1C from baseline were measured before and after ± 12 weeks of intervention where patients received the herbal or placebo with the dose of 3 × 10 drops a day. Jamu X+metformin showed a significant reduction in FPG compared to placebo+metformin at week 12 (p < 0.05). The decrease of FPG in herbal group was 28.53 ± 32.56 mg/dL, while that in placebo groups was 1.64 ± 28.98 mg/dL (P = 0,023). Meanwhile, the decrease in parameter of 2h-PPG and HbA1C were not significant. Number of adverse events occurred in the Jamu X group was 39 incidences, while that in the placebo group was 16 incidences. However, the adverse events of the herbal preparation was diminished in the second and third month. In conclusion, the Jamu X can be used as complement for metformin therapy in patient with type-2 diabetes mellitus.
