ABSTRACT
The exocarp, mesocarp, and seeds of C. pubescens have been reported to consist of flavonoid and phenol that contribute to analgesic activity. The aim of this study was to determine the analgesic effect of the exocarp, mesocarp, and seeds of C. pubescens fruit using the writhing method. A total of 24 male Swiss-Webster mice were used in this study. Mice were induced intraperitoneally using 0.5% acetic acid, and the writhes were calculated within 1 h. The result indicated that the percentages of writhing protection of the exocarp, mesocarp, and seeds of carica at a dose of 20 mg/kg were 14.13%, 26.04%, and 16.62%, respectively. However, at a dose of 40 mg/kg, the corresponding percentages of protection were 61.77%, 29.64%, and 62.33%. It can be concluded that Ethanolic Extract of carica’s Exocarp (EECE) and Seeds (EECS) has an analgesic effect at the dose of 40 mg/kg, whereas the Ethanolic Extract of Carica’s Mesocarp (EECM) does not have a significant analgesic effect.
