ABSTRACT
Dyslipidemia is an important factor of cardiovascular disease. Sugar apple (Annona squamosa L.) fruit is empirically used to decrease the blood lipid. The aim of this study was to investigate the effect of the ethanol extract from sugar apple peel on lipid profile. Sprague–Dawley rats were given high-cholesterol food for 14 days. A total of 30 rats were divided into six groups, namely normal (I), negative (II) and positive/simvastatin control (III), and test groups, including extract doses of 125 (IV), 250 (V), and 500 mg/kg (VI). After 2 weeks, total cholesterol and triglyceride levels were decreased by 14.43%, 38.26%, 48.95%, 28.10%, 57.12%, and 65.22%, whereas HDL cholesterol levels were increased by 21.19%, 36.57%, and 40.30% in groups IV, V, and VI, respectively. There was no significant difference in total cholesterol and HDL cholesterol parameters between groups III and VI. The study showed that sugar apple peel can improve the lipid profile by lowering total cholesterol and triglyceride levels and increasing HDL cholesterol levels.
