ABSTRACT
The aim was to study the biological characteristics of a new biomembrane (MES mineralized exoesqueletum shrimp) developed from the exoskeleton of paleomonetes. These studies were developed both in vitro (human osteoblastic cellular cultures and immersion of the membrane in modified synthetic plasma) and in vivo (soft tissue in lab mice and hard tissue in rabbit model). The cellular growth in the MES membrane was very exuberant in cellular culture with osteoblastic colonization on its surface (histophilic and biocompatible). After the immersion in modified synthetic plasma during one week, a mass mineralization occurred throughout the membrane’s surface (bioactive). The analysis of histological samples from experimental surgery in lab mice showed that the MES membrane wasn’t toxic to soft tissues and that it caused a moderate chronic inflammatory response (first reabsorption signs at 8 weeks). The analysis of histological samples from experimental surgery in lab rabbits showed that the MES membrane induced GBR in the created bone defect in a faster and more effective way than the physiological regeneration occurred in the control bone defect (first signs of reabsorption at 8 weeks). It has properties of “tent effect”.
