ABSTRACT
This chapter presents an overview of an experimental approach of bioinformatics tools to study the advancement in Post translational Modifications (PTMs). ProP 1.0 server predicts arginine and lysine propeptide cleavage sites in eukaryotic protein sequences using an ensemble of neural networks. This server is combined with the SignalP server predicting the presence and location of signal peptide cleavage sites. The NetPicoRNA 1.0 server yields neural network predictions of cleavage sites of picornaviral proteases. NetCorona predicts coronavirus 3C-like proteinase cleavage sites using artificial neural networks on amino acid sequences. PTM is a biochemical mechanism in which amino acid residues in a protein are covalently modified. It is crucial for regulating conformational changes, activities, functions of proteins, and is part of most of the cellular processes. Bioinformatics centered methods produces fast and valuable information to determine the PTMs information, which plays critical role in define the mechanisms of protein.
