ABSTRACT
Hepatocellular carcinoma (HCC) is a one of the cancers responsible for a significant number of morbidity and mortality rates worldwide. Previously, several researches have manifested that alteration in microRNAs (miRNAs) expression is a common feature of cancers including HCC. Moreover, many non-encoding RNAs and miRNAs have been established to possess many essential roles in the different biological processes involved in HCC progression. Genome-wide analysis of miRNA expression and many bioinformatic studies has provided us comprehensive insight into the role of HCC-related miRNAs. In addition, study of the function and mechanisms of miRNAs has provided a view into the association with the HCC pathogenesis and progression. In this present monograph, HCC promoting and HCC suppressive roles and fundamental mechanisms of certain noteworthy miRNAs have been elucidated. In addition, the identification of miRNA and gene association and recent progress in the potential application of miRNA in diagnosis and therapy of HCC are also under research.
