ABSTRACT
Osteoporosis, literally "porous bone," is defined as a reduction in the mass and quality of bone and/or the presence of a fragility fracture. Osteoporosis can be a clinically silent systemic skeletal disease characterized by compromised bone strength, predisposing to an increased risk of fracture. This chapter presents the pathophysiology of osteoporosis to guide clinicians to early diagnosis and metabolic interventions. As the author explores the pathophysiology of osteoporosis, he finds that underlying mechanisms rather than broad organ system classifications may cast more light on the underlying causes of osteoporosis. Peak Bone Mass (PBM) is an essential factor in preventing osteoporosis, with an increase of PBM of 10% considered to reduce the fracture risk by 50%. There are numerous over-the-counter and over-the-internet supplements targeting bone health and while many are indeed beneficial, some may be ineffective or indeed detrimental.
