ABSTRACT
This chapter reviews the achievements of nanoscience used in improving Central Nervous System (CNS) delivery. Improvement of CNS delivery applying new technologies could solve delivery problems of traditional pharmacotherapy and imaging of CNS disorders, for example, reduce drug trafficking and requires high dose of agents which result in toxicity and defect of medical process. Brain blood barrier trafficking is limiting factor of CNS pharmaceutical agents' kinetic, which need more interest in CNS drug designing. Polymeric nanoparticle especially Polybutylcyanoarylate nanoparticles coated with polysorbates 80 is widely being used in CNS drug delivery. Single-Photon Emission computerized tomography, Positron Emission tomography, and Computerized Tomography are another extra scanning technics which could be applied in CNS pharmacokinetic in addition to MRI. Liposomes, bilayer amphiphilic vesicle with unilamellar or multilamellar structure with low toxicity, could carry both hydrophilic and hydrophobic agents so that, these properties make this colloidal systems promising in CNS drug delivery improvement.
