ABSTRACT
This chapter discusses the possibilities in enhancing effectiveness of the radiation and chemotherapy treatments when combined with electroporation. The major modalities of cancer treatment so far developed are surgery, chemotherapy, and radiotherapy. Physical and biophysical techniques have played an important role in the diagnostics and therapeutic strategies for the treatment of diseases. In this respect, use of biophysical principles, methodologies, and instruments has provided new and sensitive approaches to cancer treatment. Cancer is a dreaded disease that continues to kill millions of people worldwide. Doxorubicin hydrochloride is widely used as an anticancer drug for various types of cancers. Although it is an effective anticancer drug, this anthracyclin derivative is known to be cardiotoxic causing various effects in patients. The effects of the treatments were evaluated in terms of tumor growth kinetics. Hence, the combination of irradiation followed by local potentiation of anticancer drugs using electroporation, a protocol which can be called radio-electro-chemotherapy, holds promise of effective therapy of solid tumors.
