Introduction

Skepticism is the inescapable provocation to reconsider arguments, reassess commitments, acknowledge ignorance, and confess prejudice. As such, it is a ubiquitous inspiration for philosophical reflection and innovation. Casey Perin investigates whether, and in what respect, the state of mind that Sextus Empiricus attributes to the skepticism can be characterized as agnostic. Martin Pickave examines medieval discussions concerning whether certain knowledge is possible and whether knowable things include substances, two debates that exert enormous influence on early modern investigations into knowledge. Martin Pickave examines medieval discussions concerning whether certain knowledge is possible and whether knowable things include substances, two debates that exert enormous influence on early modern investigations into knowledge. Markus Gabriel argues that skepticism about the knowledge as such presupposes an illegitimate metaphysical conception of the world, whose abandonment reveals people's ways of knowing to be contextual, fallible, and non-unified.