One of the first and most famous cases of the so-called “frontal lobe syndrome” was the patient Phineas Gage, described by Harlow (Harlow, 1848,1868). Phineas Gage was a railroad construction worker, and survived an explosion that blasted an iron tamping bar through the front of his head. Before the accident, Gage was a man of normal intelligence, energetic and persistent in executing his plans of operation. He was responsible, sociable, and popular among peers and friends, After the accident, his medical recovery was remarkable. He survived the accident with normal intelligence, memory, speech, sensation, and movement. However, his behavior changed completely. He became irresponsible, untrustworthy, and impatient of restraint or advice when it conflicted with his desires.