ABSTRACT
In this light, a focused overview pertaining to the synthesis of structurally diverse aliphatic and aromatic
α
-chiral primary amines is presented.
Strategies allowing facile access to a wide variety of
α
-chiral primary amines, from commodity chemicals, are central to the material presented here. The unspoken goal of this aspiration is a onestep technology capable of
α
-chiral amine synthesis from an inexpensive starting material which itself must be represented by a structurally diverse number of members. While we are not yet there, some of the methods developed in the last 5 to 10 years are on the cusp of this ambition, making it technically feasible to synthesize these compounds with high enantioselectivity, but often without industrial applicability. The intent here is to show methods that will help define the next trends in process research. Examples are provided and help define the challenges that remain, and hopefully inspire the development of the next generation of concepts and solutions. Of particular note,
aliphatic
α
-chiral primary amines are discussed because of a historical lack of success regarding their efficient synthesis.
