ABSTRACT
This chapter describes the transdermal applications of nanoparticulate by the depth of skin to which nanoparticulates are delivered: stratum corneum adsorption, percutaneous absorption, and whole skin penetration. Nanoparticulates indicate various types of subsidiary concepts of particulates that can be represented as capsules, aggregates, powders, crystals, micelles, emulsions, complex, and vesicles. The typical difference of a nanoparticulate system applied in the cosmetic industry from that of the pharmaceutical industry is that the major delivery method is very limited to the topical application of spreading onto skin surfaces, and it also serves the emotional function of provided beauty and psychological satisfaction. Although the nanoparticulate system may succeed in penetrating the stratum corneum, the efficiency of delivering the drug into the circulation system can be downgraded if the drug cannot permeate the epidermal and dermal layer or cannot avoid various types of existing defense systems in skin.
