ABSTRACT
Filtration-and membrane-based separation operations are used in the manufacture of many pharmaceutical products. These operations range, for example, from the clarification of fermentation broths used in the production of antibiotics, to virus clearance for plasma-derived protein therapeutics, to sterile filtration of heat-labile products, and beyond. Innovations in membrane materials and module design allow membranes to be used in an increasingly wider range of manufacturing steps. This chapter describes different membrane technologies and their applications during the manufacture of pharmaceutical products such as antibiotics, plasma-derived proteins, active pharmaceutical ingredients, and parenterals (small and large volume).
