ABSTRACT
KEY POINTS ■ LDL-C is a critical factor in all stages of atherogenesis and is an independent risk factor in all
population studied. ■ LDL-C magnifies cardiovascular when other risk factors are present. ■ Cardiovascular risk reduction occurs in direct relation to the degree of LDL-C-lowering. ■ Intensity of LDL-C-lowering therapy is guided by the level of risk. ■ Lifestyle therapy is indicated for all patients with LDL-C above goal. ■ Statins are the drugs of choice for reducing cardiovascular risk. ■ Combination drug therapy may be considered for patients at high risk.
