T Cell Dynamics and the Role of Apoptosis in HIV Infection

Introduction ....................................................................................................................................319 Inappropriate T Cell Apoptosis: Direct HIV-Induced Cytopathicity and CD4 Cross-Linking....320 T Cell Exhaustion Induced by Continuous High T Cell Turnover...............................................321 Interference with Thymic Function ...............................................................................................322 Appropriate T Cell Death: Chronic Immune Activation in HIV Pathogenesis ............................324