ABSTRACT
Several cosmetic ingredients have been shown to be comedogenic using the rabbit ear assay (1,2). On the basis of the animal assay and short-term human clinical studies, the development of comedones has been attributed to prolonged use of cosmetics (1,2). Although there are limitations of the rabbit model in the application of test results to humans (1-4), much information on the comedogenicity of topically applied substances has been based on the rabbit ear assay because it permits rapid screening of many possible offenders. The present chapter is concerned with this theme and reports our finding on the activity of certain raw materials previously investigated.
