ABSTRACT
Nowadays, biomedical diagnostic, clinical analysis, and nanomedicine need tools, devices, and systems with highly automated operations, fast analysis, low volume analysis, and sensitivity similar to existing large-scale analysis equipment. Small size and robust mechanics are important to design cost-effective and easy-to-use portable devices for routine applications. Such systems are called micro-total analysis systems (m-TAS) (all steps are concentrated in one system) and were introduced in 1990 by Manz et al.1 The major approach is based on continuous ow methods. Among them, most involve liquids pumped through tubing, while others use centrifugal force or gravitation for liquid displacement. An alternative to a heavy process such as centrifugation is to manipulate
and control reagent-coated paramagnetic particles to magnetically induced chemical analysis (MICA). In this case, the magnetic particles act as a magnetic eld stimuli responsive carrier.
