ABSTRACT

Exanthematous or morbilliform eruptions are the most common type of cutaneous drug reaction. This type of eruption usually begins within a week of onset of therapy, but it may occur more than 2 weeks after initiation of the therapy or up to 2 weeks after use of the drug has been discontinued. Ampicillin, penicillin, and cephalosporins are commonly associated with morbilliform eruptions. A fixed drug eruption is one or several lesions that recur at the same anatomical location on rechallenge with the medication. The genital and facial areas are common sites of involvement. Phenolphthalein, barbiturates, salicylates, and oral contraceptives have been implicated in the cause of fixed drug eruptions.