ABSTRACT

Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 315 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 316

Cell migration is an essential feature of both normal and pathological biological phenomena. Tissue formation in embryonic development requires cell movements and coordination among cells. Migration of cells plays a fundamental role in immune response and tissue homeostasis in mature multicellular organisms. It is also the main process of metastasis dissemination and tumor invasion in cancer.