ABSTRACT
For almost 50 years, epidemiologic studies have suggested a relation between fat consumptionandriskofcoronaryheartdisease(CHD).Intheearly1950s,controlled feedingstudiesdemonstratedthatfatinfoodincreasedserumcholesterolconcentrationinhumans.Directcorrelationbetweendietarylipids,totalcholesterollevels, andcoronary-relatedmortalitywasshowninSevenCountriesStudy(Keys1980). Following epidemiological studies found that not only increased serum cholesterol butalsodietarylipidsconsumptionseemedtoleadtoriskofCHDinhumanpopulation.Thesediscoveriesledtotheclassicdiet-hearthypothesis,whichpostulateda primaryroleofdietarysaturatedfatandcholesterolasthecauseofatherosclerosis and CHD in humans.
