ABSTRACT
The discovery that discodermolide’s mechanism of action is similar to that of Taxol (2)5 (Taxol is a registered trademark of Bristol-Myers Squibb Company, NY), coupled with its limited supply from the natural source, prompted the scientiœc community to prepare synthetic 1 and its analogs via a number of routes. The unique chemical structure with 13 stereogenic centers posed a major
10.1 Introduction .......................................................................................................................... 241 10.2 Natural Sources ....................................................................................................................242 10.3 Chemistry ............................................................................................................................. 243 10.4 Synthesis ...............................................................................................................................244
