ABSTRACT
This chapter* assesses the dose-response features of neuroprotective agents, and both describes the capacity of very low doses of neuropharmacological agents to act on the nervous system and, in this way, presents insight to the šelds of nanoneuropharmacology and nanoneuropharmaceutics. Despite its importance in drug evaluation and clinical applications, nanoneuropharamacology and hormetic effects have remained surprisingly underserved topics, and until quite recently, general assessments of the quantitative features of the very low dose responses of neurotropic agents have been lacking. This has limited the amount and quality of available
Introduction ..............................................................................................................69 Nerve Cell Survival .................................................................................................. 70
Integrated and General Summary ........................................................................ 70 Neurite Growth ........................................................................................................ 75 Astrocytes ................................................................................................................77 Mechanisms .............................................................................................................77 Clinical Implications ................................................................................................77 Epistemic Issues and Potential .................................................................................84 Philosophical and Ethical Grounding ......................................................................87 References ................................................................................................................88
information about the overall characteristics of the dose-time response, the magnitude of effects, the therapeutic dose-range, variability across biological models, and mechanistic explanations that putatively account for such dose-response features.
