ABSTRACT
Aerosol exposure is the most probable route in a biological warfare or terrorist attack [1]. In natural aerosol infections, only a few biological agents are considered either obligate or opportunistic airborne pathogens (e.g., Mycobacterium tuberculosis, in¦uenza) [2]. Because natural aerosol infection is a poor surrogate for studying airborne infection, modeling these interactions within a controlled experimental setting allows for intensive study of the process of aerosol-acquired disease. The modern history of studying aerosolized infectious disease agents using a homogenous synchronized experimental aerosol dates back to early twentieth-century efforts involving the infection of guinea pigs with aerosolized M. tuberculosis [3]. From these early studies to present-day investigations, important distinctions can be drawn between modeling natural infection and experimental infection. Natural infection, or the use of the communicability of an infectious agent to cause disease, is very much
5.1 Introduction ....................................................................................................65 5.2 General............................................................................................................66 5.3 Aerosol Test Facilities and Systems................................................................66
