ABSTRACT
Emerging from recent research has been the understanding that depression involves a complex and bidirectional interaction between the immune system and the central nervous system (CNS) (Gold and Irwin 2006). It is now generally accepted that immune dysregulation plays an important role in the etiology and pathogenesis of major depression. There is growing evidence that the increased production of proin¡ammatory cytokines during stress, immune, or in¡ammatory responses can exert powerful in¡uences on the CNS.
