ABSTRACT

Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are synthesized in the highest quantities by the young adult human adrenals and are the most abundant circulating steroids in the human organism (Milgrom 1990). The plasma levels of DHEA show a characteristic age-dependent

Introduction ......................................................................................................................................87 General ........................................................................................................................................87

Biosynthesis .....................................................................................................................................88 The Mitochondrial Connection ...................................................................................................88 DHEA Biosynthesis in the Brain ................................................................................................88