ABSTRACT
Evidence of inammatory mechanisms at play can be found in almost all skin diseases-either as primary culprits or as secondary features. Common clinical examples of inammation as the prime mover include psoriasis, atopic dermatitis (eczema), contact and irritant dermatitis, the immunobullous disorders (pemphigus , bullous pemphigoid, dermatitis herpetiformis, and linear IgA disease), the dermatologic manifestations of autoimmunity (lupus spectrum disorders, rheumatoid arthritis, inammatory bowel disease, dermatomyositis, and the sero-negative arthritides), and the newly described autoinammatory disorders (neonatal onset multisystem inammatory
6.1 Introduction .................................................................................................. 131 6.2 Primary Inammatory Dermatoses .............................................................. 132
6.2.1 Psoriasis ............................................................................................ 132 6.2.2 Atopic Dermatitis ............................................................................. 134 6.2.3 Autoinammatory Disorders ............................................................ 138
6.2.3.1 Cryopyrin-Associated Periodic Syndromes ....................... 138 6.2.3.2 Tumor Necrosis Factor Receptor-Associated Periodic
Syndrome ........................................................................... 142 6.2.3.3 PAPA Syndrome ................................................................ 142 6.2.3.4 Acquired Autoinammatory Syndromes ........................... 143
6.3 Secondary Inammatory Dermatoses .......................................................... 144 6.3.1 Acne Vulgaris ................................................................................... 144 6.3.2 Rosacea ............................................................................................. 145
Acknowledgments .................................................................................................. 146 References .............................................................................................................. 146
disorder, familial cold urticaria, Schnitzler syndrome). In many of these conditions, inammation is identišed as primary in pathogenesis simply because the ultimate trigger is yet to be identišed. Examples of inammation as a secondary phenomenon include acne, rosacea, ulcers, stasis dermatitis, skin cancers, and the excoriations of pruritic disorders and psychodermatoses.
