ABSTRACT
DBS has proven to be a safe and effective therapy for tremor, dystonia and many of the motor features of advanced Parkinson’s disease (PD). The parameters of the electrical stimulus can be easily and reversibly modulated to optimize symptom control and minimize side effects, such that DBS has almost entirely replaced ablative surgery. With probably more than 90,000 individuals implanted worldwide, experience has accumulated sufficiently to allow us to take a look at what we have learnt and how this technology is likely to be developed and applied in the future.
