ABSTRACT
The purpose of this chapter is to consider whether clinical interventions might evolve toward restitution of normalized metabolic and neurophysiologic activity following traumatic insult to the brain. To accomplish this, bioscience research and clinical trials will have to focus on complex cellular neural networks under tremendous physiologic strain and consider the recovery demands that this system must achieve. Can we treat cellular metabolic challenges, prevent or reverse early structural senescence, or promote neurogenesis, synaptogenesis, angiogenesis, and gliogenesis needed for neurologic remodeling after brain injury? The following discussion may provide some clues or potential pathways to optimization of function in the injured or recovering central nervous system (CNS).
