ABSTRACT
Children are not simply small adults and it follows that children may exhibit differential sensitivity to drug-induced adverse events. This also applies to drug-induced liver injury (DILI). As an embryo develops, leading to the birth of a child, and eventually maturation into an adult, the human body goes through many different developmental phases. Various factors may make the developing human more or less susceptible to DILI when compared to adults. This chapter reviews the major developmental phases of the maturing liver with an emphasis on phases that may pose unique sensitivities to DILI. A review of the pediatric DILI literature is then presented.
