ABSTRACT
Wound healing is the process by which damaged tissues are repaired through the ordered replacement of damaged cells and simultaneous remodeling of the extracellular matrix (ECM), and is critical for survival [1]. An ideal end point for healing is regeneration that entails complete restoration of original tissue form and function. But the process of scarring interferes with regenerative or normal healing sequelae, preventing normal restoration of anatomical form and, when extensive, can impair physiological function. Speciœcally, scarring of internal organs-pulmonary œbrosis, liver cirrhosis, renal glomerulosclerosis, and cardiac œbrosis-often cause organ failure and mortality [1]. Furthermore, cutaneous scars are most commonly associated with cosmetic disœgurement while organ œbroses can be accompanied by pruritis, dysesthesia, and pain [2].
