ABSTRACT
Introduction ............................................................................................................ 376 Public Health Perspective ...................................................................................... 376 Evolutionary Context ............................................................................................. 377 Benets of Nutrigenomics for Public Health ......................................................... 379
Predictive Power of Nutrigenomics .................................................................. 379 Addressing Epidemiologic Questions: Chemoprevention Trials ...................... 381
Applications of Nutrigenomics .............................................................................. 382 Colorectal Cancer .............................................................................................. 383 Nonalcoholic Fatty Liver Disease .....................................................................384
Methodological Challenges in Public Health Nutrigenomics ................................ 385 Measurement Accuracy and Reliability ............................................................ 385 Study Design ..................................................................................................... 386 Sample Size and Power ..................................................................................... 386 GWAS versus Candidate Gene Analysis Studies .............................................. 387 Data Analysis and Management ........................................................................ 388 Capturing Human Heterogeneity and Diversity ................................................ 388
Implementation of Nutrigenomics in Public Health Practice ................................ 389 Practical Impact ................................................................................................. 389 Literacy and Training ........................................................................................390 Cost Efcacy of Nutrigenomics ........................................................................390 Potential for Behavior Change .......................................................................... 391 Other Considerations ......................................................................................... 391
Emerging Directions and Future Progress ............................................................. 391 Acknowledgments .................................................................................................. 392 References .............................................................................................................. 392
